BIOLOGY 10
GENETICS
7 SEP 00
MEETING 2

GOOD MORNING! ANOTHER BEAUTIFUL DAY

OUR FIRST LAB MEETING IS NEXT WEEK ON BOTH TUESDAY AND WEDNESDAY; PLEASE READ THE PAPERS IN THE LAB (THEY WILL SHORTLY BE ON e-res). WE WILL DISCUSS THESE PAPERS IN SEMINAR FORMAT.

JBJ AND TOM WILL BE AVAILABLE ON FRIDAY (TOMORROW) AT 3:30 TO ANSWER ANY QUESTIONS YOU MIGHT HAVE AND TO HELP IN ANY WAY WE CAN.

TEXT READING: CHAPTERS 1 AND 2 FOR THE NEXT COUPLE OF LECTURES.

This morning we will complete our discussion of whether mutations are pre-adaptive or post adaptive then move on to discuss the basic principles of genetics as discovered by Gregor Mendel. We shall also discuss the fact that Mendel's data actually fit expectations too closely. Mendelism is rooted in probabilities, so we shall look at how probabilities play a role in some genetic counseling situations, though we shall not get to this topic in all probability( until next week.

PRE-ADAPTIVE VERSUS POST-ADAPTIVE MUTATION: WHICH IS IT?

Luria and Delbruck (1943): The Fluctuation Test
Newcombe (1949): The Spreading Technique
Lederberg and Lederberg (1952): Replica Plating

MUTATIONS PRODUCE GENETIC VARIATION --- THE ESSENCE OF EVOLUTION

GENETIC VARIATION: INHERITANCE PATTERNS

Mendelism: The Laws Governing the Transmission of the Genetic Material

The principle of segregation
pure line
allele
dominant/recessive
random fertilization
homozygous/heterozygous
genotype/phenotype
backcross/testcross
The principle of independent assortment
dihybrid cross/monohybrid cross
punnett square
forked line
trihybrids and more

PROBABILITY: A KEY ELEMENT OF MENDELISM

Were Mendel's results too good to be true?
Probability and genetic counseling

FONT SELECTED BY JESSICA ROSE JENKINS