SWARTHMORE COLLEGE
FALL 2000
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John B. Jenkins, Professor of Biology
Office: Martin 304
Lab: Martin 306
Phone: 8052
e-mail: jjenkin1
Office Hours: Tuesday afternoons; Friday 3:30 to 5:00; and by appointment (during lab is also possible)
Thomas Valente, Laboratory Instructor
Office: Martin 102
Phone: 8630
Text: AN INTRODUCTION TO GENETIC ANALYSIS, 7th ed., 2000. Griffiths, A.J.F., et. al.; Freeman, New York (Solutions Manual …. Optional; 1 copy in lab)
Grading:
Two Hourly Exams: 200 points (3 October; 14 November)
Final exam: 200 points (100 new; 100 review)
Miscellaneous assignments: (i.e. homework assignments, short reports, etc.): 100 points
Lab: 200 points (Various assignments; Laboratory Notebook)
Total Points: 700
2000
(number in parenthesis refers to text chapters)
WEEK 1. 05, 07 SEP Introduction; Basic Mendelism. (1, 2,)
WEEK 2. 12, 14 SEP Advanced Mendelism and Probability. (4)
Meeting3 Lecture Outline
WEEK 3. 19, 21 SEP Mendelism in Humans; Meaning of Dominant and Recessive (8, 9, 10 for DNA background)
WEEK 4. 26, 28 SEP Chromosomal Basis of Inheritance (3)
WEEK 5. 03#, 05** OCT QUIZ 1; NO CLASS THURS (ASHG MEETING)
WEEK 6. 10, 12 OCT Nonmendelian Inheritance Patterns: Extranuclear Genes; Genomic Imprinting (21)
WEEK 7. 17, 19 OCT FALL BREAK!!!!!!!!!!!!!!!!!
WEEK 8. 24, 26 OCT Quantitative Genetics: Polygenes, Environment, Behavior (25)
WEEK 9. 31, 02 NOV Basic Strategies of Gene Mapping in Eukaryotes (5)
WEEK 10. 07, 09 NOV Mapping the Human Genome (6, 12*, 13*, 14*)
WEEK 11. 14#, 16 NOV QUIZ 2; Positional Cloning: Isolating Genes by Position (12*, 13*, 14*);
WEEK 12. 21, 231 NOV Mechanisms of Recombination (19)
WEEK 13. 28, 30 NOV Viral and Bacterial genetics (7)
WEEK 14. 05, 07 DEC Regulation of Gene Expression in Prokaryotes: The Lac Operon; Lysogeny (10*, 11)
WEEK 15. 12 DEC Regulation of Gene Expression in Eukaryotes: Sex Determination; Cancer (22*, 23*)
* PARTS OF THESE CHAPTERS RELATE DIRECTLY TO THE MATERIAL BEING DISCUSSED IN CLASS; OTHER PARTS OF THE CHAPTER WILL NOT BE EXTENSIVELY DISCUSSED IN CLASS AND ARE TO BE READ FOR BACKGROUND PURPOSES (OR PERSONAL INTEREST) ONLY.
** NO CLASS MEETING (ASHG MEETINGS)
# QUIZ
1 THANKSGIVING HOLIDAY
WEEK OF LABORATORY EXERCISE
9/4 -- NO LAB
9/11 1 INTRODUCTION TO GENETIC ANALYSIS ORGANISMS COMMONLY USED IN GENETICS; DISCUSSION OF IMPORTANT HISTORICAL PAPERS
9/18 2 BASIC MENDELISM; DATA ANALYSIS
9/25 3 COMPLEMENTATION; EPISTASIS
10/2 -- NO LAB MEETING (ASHG MEETINGS)
10/9 4 DISCUSSION OF 2 AND 3; CHROMOSOMES
10/16 5 FALL BREAK
10/23 6 GENE MAPPING
10/30 7 CHEMICAL MUTAGENESIS
11/6 8 PCR I: DNA ISOLATION AND AMPLIFICATION
11/13 9 PCR II: ELECTROPHORESIS
11/20 10 INTRODUCTION TO BACTERIAL VIRUSES
11/27 11 VIRAL GENE MAPPING AND COMPLEMENTATION ANALYSIS
12/4 12 POPULATION GENETICS AND EVOLUTION
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